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Endothelial cells contain 20-fold more acid sphingomyelinase (ASMase) than any other cell in the body. ASMase hydrolyzes sphingomyelin, which is preferentially concentrated in the outer leaflet of the plasma membrane of all mammalian cells, to generate the second messenger ceramide. We initially showed that high dose ionizing radiation activates endothelial cell ASMase, thereby inducing apoptosis and microvascular dysfunction in multiple murine organs, and that ASMase KO mice are resistant to all clinically-relevant radiation doses (Santana et al., Cell 1996, 86:189-199). Our lab was studying normal tissue damage prior to 9/11 and showed that ASMase/ceramide mediated vascular damage played a fundamental role in lethality from the Gastrointestinal-Acute Radiation Syndrome (GI-ARS) in mice...
The Gastrointestinal Oncology Service in the Division of Solid Tumor Oncology, Department of Medicine, is seeking an investigator with expertise in translational and clinical research focused on gastroesophageal cancers. This investigator will be appointed as the Debbie’s Dream Foundation Gastric Cancer Investigator and will play a pivotal role in advancing patient care, research, and education in esophageal and gastric cancers. This is an exciting opportunity for a dedicated researcher to join one of the world's leading cancer centers. Under the mentorship of Dr. Yelena Janjigian, Chief of the Gastrointestinal Oncology Service, the investigator will have up to one year (with the possibility of extension) of protected research time to focus on biomarker development, laboratory...
The largest of MSK’s clinical departments, the Department of Medicine encompasses experts in solid tumor oncology, hematologic malignancies, subspecialty medicine and supportive and acute care services. Offering a range of services both in multiple sites in New York City and at their suburban outpatient locations in our Regional Care Network (RCN), DoM physicians oversee the care of the whole patient. Refer to the Department of Medicine Web page for additional information about the department and its services. The Lymphoma Service in Division of Hematologic Malignancies the Department of Medicine is seeking a full-time Academic Clinician and a Clinician Researcher at the Assistant Attending level or higher focused on the care of patients, education and research at our Manhattan...
Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers. MSK ranks in the top 20 on Forbes’ list of America’s best employers for diversity (MSK Ranks in Top 20 on Forbes’ list of America’s Best Employers For Diversity). The largest of MSK’s clinical departments, the Department of Medicine (DoM) encompasses experts in solid...
Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers. MSK ranks in the top 20 on Forbes’ list of America’s best employers for diversity (MSK Ranks in Top 20 on Forbes’ list of America’s Best Employers For Diversity). The largest of MSK’s clinical departments, the Department of Medicine (DoM) encompasses experts in solid...
The Department of Medicine is seeking a highly motivated and successful individual with a background in Internal Medicine or Emergency Medicine. Working in our State of the Art Urgent Care Center, the clinician will be evaluating and managing acutely ill patients with complications of their malignancy, cancer care or chronic health conditions. Open round the clock, year round, the provider will determine whether hospitalization, discharge, or observation care is appropriate. The provider is part of a dedicated team operating at our Manhattan campus and may rotate to any of our Regional Sites with smaller facilities. He/She will also participate in providing night, weekend, holiday, and backup coverage. He/She may be involved in video triage, remote care, as well as supervision of a team...
The Radiation Dosimetry Core and MRI Physics group at Memorial Sloan Kettering Cancer Center (MSKCC) offer a postdoctoral research fellow or research associate position in MRI-guided radiotherapy. The successful candidate will work under the supervision of Grace Tang, a leader in the development of MLC tracking techniques. The main goal of the position is to develop real-time MRI-guided radiotherapy technology via MLC tracking on the MR-linac system for tumors affected by continuous motion. The work involves building machine control interface, experimental validations, and clinical feasibility testing.. The Department of Medical Physics consists of over eighty faculty physicists and computer scientists plus support staff working on various physical problems related to diagnosis...
Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers. The largest of MSK’s clinical departments, the Department of Medicine (DoM) encompasses experts in solid tumor oncology, hematologic malignancies, subspeciality medicine and supportive and acute care services. Offering a range of services both in multiple sites in...
We have an opening for a hybrid research and radiotherapy physics residency position in the Department of Medical Physics, with a flexible start date for the right candidate. This is a hybrid residency program in which a two-year grant-funded research project is followed by a two-year clinical residency in radiotherapy physics. Those who enter the 4-year program without CAMPEP credentials will be enrolled in a CAMPEP Certificate program with full tuition support from the department. You will be required to complete a Certificate program during the first two years of the program before entering clinical training. Research for this position will be conducted under Dr. Xiang Li, Ph.D., DABR, on a project titled “Deep Learning Empowered Target Decomposition Technique for Markerless...
The Leukemia Service in the Division of Hematologic Malignancies, Department of Medicine, at Memorial Sloan Kettering Cancer Center is seeking a full-time mid-to senior level Clinical Investigator to lead the Program in Myelodysplastic Syndromes. The Leukemia Service at MSKCC consists of 20 clinical and laboratory based faculty engaged in the clinical care of patients with myeloid and lymphoid malignancies, innovative clinical and translational research, and education. Our clinical and research programs span across our Manhattan, New Jersey, Westchester and Long Island campuses. This position will come with significant resources to enable the expansion of our current MDS clinical and research program. Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer...
