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We currently have a postdoctoral position available in the Jonathan Coleman Laboratory in the Department of Surgery at MSKCC. The laboratory’s focus is on developing and translating a local ablation therapy called Vascular targeted photodynamic therapy (VTP) for the treatment of cancers as well as assessing its immune modulatory mechanism. VTP is being developed to treat multiple types of cancers including patients with prostate, urothelial and lung cancers. Dr Coleman is leading multiple clinical trials at MSKCC and other centers. Our laboratory performs efficacy and safety studies of VTP and investigates its impact on tumor microenvironment to understand its immune modulatory effect. This will help develop combination of VTP/immune therapy leading to better clinical outcome. We use both syngeneic preclinical models as well as patient derived xenograft/organoids models developed in the lab to assess treatment effect. In addition, we analyze patient samples from pre- and post-treatment using flow cytometry, genomics and single cell RNA-seq to understand disease biology and treatment effects. Responsibilities include working directly with the senior PhD (lab manager) to design, develop, and execute bench experiments and performing data management. Additionally, he/she will analyze experimental results to derive logical conclusions, draft experimental procedures, prepare manuscripts pertaining to research work, and maintain detailed laboratory records. The ideal candidate will have a PhD with a background in immunotherapy/immunology, a passion for science, and a desire to advance the understanding and treatment of cancer. A highly organized and self-directed individual with strong interpersonal skills and the ability to work in a dynamic environment is desired. The candidate should have experience with and be willing to work with mouse models and should be comfortable with the handling of human tissue samples. Please include CV, bibliography, brief statement of research interests, and names and details of three references in your application.
Postdoctoral positions are currently available to study mechanisms of microbiome influence on host immunity utilizing mouse models. Successful candidate will have expertise in immunology and will employ a broad range of molecular, microbial, immunological and systems-level techniques across disciplines, and will join a dynamic, collaborative group. REQUIRED QUALIFICATIONS- Ph.D. or equivalent degree in molecular biology, immunology, microbiology or related fields- Publication(s) in a peer reviewed journal- Clear and effective communication skills- Scientific creativity, reliability, and independence in research- Research experience and/or demonstrated interest in host-microbial interactions Please submit a cover letter, CV and 3+ references to:email@example.com #LIPOST
In this position you will be contributing to the design, development, optimization and implementation of bioconjugation techniques and related processes predominantly involving antibodies, other proteins and nucleic acids. The goal is to expand and improve the capabilities of digital pathology by improving and facilitating multiplexed tissue imaging techniques. You are! - Responsible for planning and synthesizing bioconjugates using established chemistries (lysine, endogenous cysteine, site specific/click-chemistry)- Enthusiastic about contributing to the development of new bioconjugation techniques- Able to purify conjugates using relevant techniques (affinity purifications, size exclusion chromatography, ion-exchange)- Capable of characterizing bioconjugates using multiple modalities (UV/Vis- Nanodrop, HPLC, MS, SDS-PAGE)- Capable of learning basic microscopy skills to test bioconjugate functionality- Enthusiastic about working in an inter-disciplinary environment with biologists- Interested in improving the capabilities of next-generation immunohistochemistry techniques and platforms as it relates to digital pathology- Capable of working closely with computational biologists, data scientists and image scientists- Adept at working independently to perform lab experiments- Organized and diligent with time management and deadlines- Creative in proposing new methods, techniques or approaches- Capable of writing data briefings and summaries on projects- Enthusiastic to train others to perform developed protocols- Diligent in maintaining clear and current records of all work To be considered for a Bioconjugation Research Scientist position, you need:- A MS (2+ yrs relevant experience) or Ph.D. (1-5 yrs relevant experience) in protein chemistry, biochemistry, chemistry, or related discipline- Experience with protein chemistry, purification, and characterization- Experience with protein analytics- Meticulous data documentation and organizational skills- Experience giving presentations to small audiences- To be fluent with Microsoft Excel, PowerPoint, and Word- Experience documenting, organizing, and tracking multiple ongoing projects - Excellent communication skills (written and oral)#LIPOST
Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers. We are looking for highly motivated postdoctoral fellows interested in investigating immune spatial heterogeneity in human cancers. These projects are based on high-dimensional tissue imaging of the tumor and associated microenvironment with single-cell protein expression analysis and subsequent integration of genomic DNA/RNA profiling. The intention is to better define the function and development of the tumor/immune ecosystem to ultimately improve patient immunotherapeutic selection and prognostication, to better understand and overcome therapeutic resistance and to improve our understanding of biologic states in space and time.In this role you will: - Collaborate with quantitative experimentalists and computational scientists to conduct and publish research in a rapidly expanding investigational field with significant room for growth and ground-level development- Use new experimental tools and design novel methods and assays to address problems in human tumor immunology- Design and actualize high-dimensional spatial profiling studies within the immunopathology lab- Work with high dimensional imaging data from a variety of cutting-edge platforms such as MIBI, Codex, Vectra/Polaris and Nanostring GeoMx- Design strategies to analyze high dimensional imaging data- Integrate imaging data with genomic DNA/RNA profiling- Correlate findings with ongoing and recent clinical trials outcomes- Author journal papers and attend conferencesThe ideal candidate should have: - PhD or MS degree in immunology- Publication record in biologic or quantitative sciences- Experience with R for data analysis and statistics- Coding skills (esp. Python) would be helpful- Recent graduates, MS, and PhD candidates who will defend soon are welcome#LIPOST
Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a Comprehensive Cancer Center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers. An opening is now available for a postdoctoral position working on a project entitled “Physics simulations for interstitial brachytherapy with recoil short-lived alpha emitting devices” under the direction of Dr. Antonio Damato. The ideal candidate should have a strong background in physics, nuclear engineering or mathematics, have working experience with mathematical modeling (e.g. finite elements, Monte Carlo), and be proficient in certain programming language such as Python, MATLAB and C/C++. Experience in modelling diffusion-convection processes is a plus. The research will focus on developing, evaluating, and implementing numerical solutions leading to dose calculation from a novel brachytherapy device releasing locally elements emitting alpha-radiation. The candidate will work closely with medical physicists with assistance from computer scientists in developing the methods. There will also be great opportunity for the candidate to get firsthand knowledge & experiences with brachytherapy and clinical medical physics. This is a full-time two-year appointment. For the right candidate, an opportunity to join a combined four-year hybrid research/residency program in Therapeutic Medical Physics in the Department of Medical Physics is available. Details of the residency program can be found at https://www.mskcc.org/hcp-education-training/residencies/residency-therapeutic-medical-physics. The successful candidate will be compensated according to the MSKCC standard rates based upon experience. Specifics information on employee benefits offered may be found at https://careers.mskcc.org/learn-about-msk/benefits/. The Department of Medical Physics consists of over seventy faculty physicists and computer scientists plus support staff working on various physical problems related to diagnosis and therapy for cancer. MSKCC has a large, cutting edge program in all aspects of radiation oncology physics that seeks to improve the clinical effectiveness of radiation therapy in partnership with radiation oncologists, radiologists and other medical professionals. Many new programs in radiation therapy research and development are ongoing, including: the development and clinical use of predictive models using machine learning/AI for treatment planning, improved treatment planning optimization algorithms, integration of MR and PET imaging into radiotherapy decision making and treatment planning, 4D imaging and motion management, the use of Deep Learning and AI for image analysis and tissue segmentations, and the development of informatics-based adaptive radiotherapy processes (www.mskcc.or/departments/medical-physics). Medical physics resources include twenty-nine linear accelerators, one combined treatment room-MRI-Linac system, six HDR units, CT, PET/CT and MRI simulators, and state of the art inter- and intra-fractional imaging and motion management capabilities. We also have access to robust high performance and GPU computing. We are also partners with the New York Proton Center, that houses one cyclotron, three rotational gantry treatment rooms, one fixed beam treatment room, one research beam room, PET/CT, two CTs, two MRIs, related clinical support space. We have astrong philosophy that all facilities will provide outstanding treatment quality as well as contribute to the overall mission of MSKCC to advance the state of cancer care. Memorial Sloan Kettering Cancer Center is located on the Upper East Side of Manhattan. Interested candidates should send a letter of interest, curriculum vitae, and list of three references via e-mail to: Christopher J. Watchman, PhD, DABREducation Director and Associate Attending PhysicistDepartment of Medical PhysicsMemorial Sloan Kettering Cancer Center1275 York Ave.New York, NY 10065 e-mail: firstname.lastname@example.org #LIPOST
Are you a synthetic chemist, polymer chemist, protein or biochemist? Are you interested in cancer biology and drug design? Then apply to our lab to work on cancer drug design, protein engineering, and cancer proteomics. We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics and the Tow Center for Developmental Oncology at the Memorial Sloan Kettering Cancer Center. We leverage proteomics to develop improved biologic therapies, computational modeling to define oncogenic mechanisms, and innovative mouse models to determine biological functions and guide clinical trials of improved treatments, particularly for children with refractory cancers. We are developing functional mass spectrometry proteomics methods to define oncogenic signaling, and develop new macromolecular cancer drugs. In particular, we have been using peptide barcoding to construct libraries of cell-penetrant peptidomimetic inhibitors of oncogenic proteins. Recently, we used this approach to successfully develop the first effective inhibitor of MYB, an essential oncoprotein in the majority of blood cancers, as recently published in Nature Communications 2018 and Elife 2021. Current efforts are focused on applying this technology for protein engineering and development of new peptide conjugates for cancer and gene therapy. An ideal candidate is a PhD graduate with experience in analytical chemistry or protein engineering, who is interested in developing an independent research programme for future faculty or scientist positions in biotechnology and drug design. We value diversity in ideas and people, and our group seeks excellence and equity in scientific discourse and scientific practice. Memorial Sloan Kettering Cancer Center is a vibrant academic community, part of the Tri-Institutional campus with Rockefeller University and Weill Cornell Medical College, located in the middle of Manhattan in New York City. We offer a unique and unparalleled research environment in cancer biology and oncology with diverse basic and applied science programs, which are directly integrated with clinical care, enabling rapid translation of improved therapies for patients. Please send a detailed cover letter describing your past research and interests and current CV to Alex Kentsis, MD, PhD at email@example.com.
As the head of the Molecular Therapeutics Initiative (MTI) at the Tow Center for Developmental Oncology (TCDO) at MSKCC, you will oversee the experimental science focused on new therapies for childhood cancers. The MTI Head will lead collaborative experimental research, maintenance of shared instrumentation, and initiation of original research in translational oncology, preclinical testing, and correlative clinical science. This is a faculty-level, non-tenure track position of considerable responsibility.The mission of the Molecular Therapeutics Initiative is predicated on the notion that improved models of childhood cancers, combined with mechanism-based translational science, can enable the development of improved therapies for patients. MTI will provide laboratory support for the identification, development, and initiation of clinical trials of new small molecule and biologic therapies, emanating from TCDO and MSK discoveries. Studies will include preclinical repurposing of approved pharmacologic agents for oncologic indications in children, preclinical investigation of emerging oncologic agents for pediatric indications, support for IND enabling studies for FDA approval of MSK developed agents, including small molecules, designer biologics, and gene and cell therapies, and development of diagnostic and pharmacodynamics assays for investigational targeted therapies and early phase clinical trial correlative studies to enable precision pediatric oncology. The MTI Head will also oversee the development of new preclinical models, including xenograft, explant and stem cell models, and collaborative research projects.Our Website: https://www.mskcc.org/research-programs/developmental-oncologyYou are:• An expert in cancer biology, including molecular and cell biology, functional genomics, mouse models, and data science• A strong problem-solver who gains satisfaction from advancing biomedical research in a dynamic and fast-paced academic environment• A creative thinker and strategic planner who engages in thinking outside the box• Adept at planning and prioritizing work to meet goals and commitments• Someone who is willing to substantially contribute to the academic activities of MSK and help define its intellectual direction for the future• A highly motivated person who is interested in the academic success of others and program buildingYou will:• Work with the TCDO Director and Members to implement new research activities of MTI. This includes the design and execution of molecular, genetic, and therapeutic studies, development of cellular and animal preclinical cancer models, and implementation of new experimental techniques and correlative biomarkers.• Oversee and hire technical personnel, maintain instruments, and develop original collaborative research projects. The Head will partner with existing capabilities including the SKI Experimental Therapeutics Center, MH Early Drug Development Service, Program for Drug Development in Leukemia, and MSK Kids Pediatric Translational Medicine Program.You need:• PhD degree in cancer biology or related discipline is required, with a documented record of expertise and excellence in translational science• Experience in oncology or medicine is preferredTo apply, please send two-page letter of interest explaining your past research, current interests, and how your past work has prepared you to succeed and enable the TCDO mission, along with your current CV to firstname.lastname@example.org #LIPOST