Senior Manager, Study Start-Up (Sr PAM)

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. 

Exciting Opportunity at MSK: We are seeking a Senior Manager, Study Start-Up, to join our growing Protocol Activation Team. As a Senior Manager, you will lead the activation of clinical research studies within your assigned services and act as the primary point of contact for activation data, metrics, and process updates. You’ll coordinate across departments—including Finance, Contracts, Nursing, Clinical Research Operations, and external sponsors—to navigate complex protocols through MSK’s activation system.

This role requires strategic thinking, advanced protocol interpretation skills, and a strong background in relationship and team management. You’ll also contribute to process improvement initiatives and help shape the future of protocol activation at MSK.
In this role you will lead the activation of clinical research studies, coordinating with other Clinical Research Administration teams to ensure that the Center's goals for Time to Activation are met. Join us today and help make a difference every day!

Role Overview:
• Lead and manage the activation of high-profile, complex clinical research protocols.
• Supervise and support a team of Protocol Activation staff, ensuring operational excellence and workload balance.
• Interpret research protocols to identify all necessary components for activation.
• Coordinate with internal and external stakeholders to facilitate timely and efficient study start-up.
• Serve as the main liaison for activation metrics and performance data for assigned departments.
• Champion improvements to the user experience and activation processes across services.
• Participate in cross-functional working groups focused on process optimization.
• Educate staff on clinical research procedures and protocol requirements.
• Prepare and analyze activation metrics to identify trends and areas for improvement.

Key Qualifications:
• Bachelor’s degree preferred; relevant experience will be considered in lieu of a degree.
• 7+ years of clinical research experience, with a strong preference for oncology.
• 4+ years of direct staff management experience.
• Deep knowledge of Good Clinical Practice (GCP), Human Subject Protection, clinical trial design, and regulatory processes.
• Advanced understanding of 21 CFR, 45 CFR 46, and HIPAA regulations.
• Proven ability to manage complex relationships and navigate cross-functional environments.

Core Skills:
• Strategic thinker with strong problem-solving skills.
• Excellent interpersonal and communication abilities.
• Experience managing high-stakes projects with multiple stakeholders.
• Passion for improving clinical research operations and user experience.

Additional Information:
• Schedule: Monday - Friday, 37.5 hours, hybrid
• Location: 633 Third Avenue, NYC
• Reports to: Project Manager, Study Start-up

Pay Range: $121,400.00-$200,400.00
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• Review Our Greats Benefits Offerings

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.  

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