Senior Research Scientist Sarcoma Cancer Research Center | Singer Laboratory @MSK

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. One of the world’s most respected comprehensive centers devoted exclusively to cancer, we have been recognized as one of the top two cancer hospitals in the country by U.S. News & World Report for more than 30 years. 

Dr. Singer’s Sarcoma Research Lab is seeking an experienced Scientist to join their NIH funded laboratory dedicated to gene target identification and drug discovery in soft tissue sarcoma through a genome-wide genetic and functional analysis.  The overall goal of the lab is to perform a comprehensive molecular genetic and functional analysis of soft tissue sarcoma, so as to elucidate the mutational programs and pathways involved in sarcomagenesis and to identify novel therapeutic targets. Sarcoma tissue samples and cell lines are subjected to a multiplatform genome-wide characterization of expression of protein-coding genes and microRNAs, DNA copy number changes, activating mutations, gene rearrangements and methylation profiling.  These data are then used to identify both genetically distinct subtypes of sarcoma and molecular signatures associated with tumor morphology, grade, recurrence, and survival.  To identify potential therapeutic targets, our lab screens the genes and microRNAs in these signatures for involvement in proliferation, differentiation, and survival of sarcoma cell lines.  Potential targets are validated by functional assays in additional cell lines and in xenograft models.  Results will be translated into new therapeutics for soft tissue sarcoma. 

The ideal candidate should have:  

• Ph.D. or equivalent in biological science  
• Proficiency in molecular and cell biology and one or more of the following areas: 

• Computational biology/NGS data analysis 
• Cancer biology 
• Genetically engineered mouse models. 

• A strong publication record (1st author peer-reviewed publications) 
• At least 5 years of experience 

Please send CV, bibliography, brief statement of research interests and names of 3 references via email (Including #SingerResearch in the subject line) to:  

Russell Holmes 

Surgery Research Lab Operations Manager 

HolmesR@mskcc.org  

#LIOnsite

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