Senior Research Scientist, Rectal, Colon and Anal Cancer Biology Colorectal Cancer Research Center | Smith Laboratory @MSK

Job Locations USA-NY-New York
Posted Date 5 months ago(4/27/2023 1:43 PM)
Requisition ID
Pay Range

Pay Range


Company Overview

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. One of the world’s most respected comprehensive centers devoted exclusively to cancer, we have been recognized as one of the top two cancer hospitals in the country by U.S. News & World Report for more than 30 years.


In compliance with applicable State regulatory authorities, COVID-19 vaccination is mandatory for all MSK staff. Staff are considered fully vaccinated upon completion of a primary vaccination series for COVID-19 (i.e., one dose of a single dose vaccine or a final dose of a multi-dose vaccine series). Exceptions from the COVID-19 vaccine requirement are permitted for those who request and receive an approved medical or fully remote exemption.  Requests for medical exemption can take up to two weeks to review. Vaccination or an approved medical exemption is required to start work.



Note: Individuals are eligible to receive a COVID-19 booster two months after completion of a primary vaccination series for COVID-19.  Because vaccine-induced immunity can wane over time, MSK continues to strongly urge all staff to get a COVID-19 booster as soon as they become eligible to maintain their protective immunity for a longer period.

Job Description

The Smith laboratory, an NCI-funded research program, in conjunction with the Surgery Department for Rectal Cancer Research, is searching for an outstanding scientist with a strong interest in translational research focused on the biology of rectal, colon, and anal cancer. The Smith laboratory focuses on improving response to neoadjuvant therapies for patients with rectal cancer by developing better disease models. Other projects in the laboratory include identifying novel radiosensitizers to take forward into phase 1 clinical trials with parallel co-clinical trials in patient-derived organoids through strong collaborative relationships with colorectal disease management team members and Dr. Paul Romesser, a radiation oncologist. We are seeking candidates with a strong molecular and tumor biology background with experience in cancer biology, along with experience with PDO and PDX animal models.


The candidate will have the opportunity to interact with investigators with expertise in the biology of rectal cancer, translational therapeutics, and molecular pathology.  


The ideal candidate should have:  

  • Ph.D. or equivalent in biological science  
  • Proficiency with organoids culture, molecular biology, biochemistry, gene expression arrays, DNA, RNA, and protein assays 
  • Experience with mouse models will be considered a definite strength 
  • At least 3-4 years of experience  


Please send CV, bibliography, brief statement of research interests and names of 3 references via email (Including #SmithResearch in the subject line) to:  


Russell Holmes 

Surgery Research Lab Manager, SKI  




MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.   


Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment. 

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