Postdoctoral Researcher – van den Brink lab Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers.

The van den Brink lab is looking for a highly motivated post-doc to work on a project involving novel T cell immunotherapies for multiple myeloma. Our lab focuses on a variety of research topics related to cancer immunotherapy, including hematopoietic stem cell transplantation, graft-versus-host disease, effects of the microbiota on transplant outcomes, immune reconstitution/thymic rejuvenation strategies, and CAR T cell therapy for various malignancies.

The CAR T cell group of the van den Brink lab designs novel CAR T cells targeting hematologic malignancies with the goal of improving T cell activity while reducing toxicities. We study CAR T cell activity in syngeneic mouse models and are currently developing xenograft mouse models. This postdoc position will focus on developing next-generation CAR T cells targeting human myeloma antigens with the goal of translating these CAR T cells into clinical application.

Lab Website: https://www.mskcc.org/research/ski/labs/marcel-van-den-brink

Responsibilities:

• Human T cell cultures and viral transduction
• In vitro cell proliferation, protein expression, cell viability, immunophenotyping, and cytoxicity assays
• CRISPR/Cas9 and gene transfer
• Generation and maintenance of tumor cell lines and virus producing-packaging lines in culture
• Xenograft models of human myeloma in mice
• Mouse handling, injection, and harvesting tissues
• Multi-color flow cytometry
• Molecular cloning of CAR constructs

The ideal candidate should have:

• PhD, MD/PhD, or MD completed in cancer immunology, immunotherapy, T cell biology, cell engineering, or related field
• Excellent verbal and written communication skills
• Solid publication record
• Experience with human T cell culture and retroviral/lentiviral transduction methods or non-viral vector modification.
• Experience with multi-color flow cytometry panels is preferred
• Experience with mouse handling and procedures is advantageous, but not required

If you have any questions about this job opportunity, please contact:

Marcel van den Brink

vandenbm@mskcc.org

Salary: $55,439-$74,263

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. 

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