Post-Doctoral Positions – Next-generation Single-molecule, Super-resolution Optical Imaging and In situ Structural Biology Approaches

Job Locations USA-NY-New York
Posted Date 2 months ago(11/29/2022 1:53 PM)
Requisition ID

Company Overview

Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians, and other health care workers.

Job Description


The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC

has immediate openings for Postdoctoral positions.


A major focus in our lab is developing cutting-edge single-molecule detection and superresolution

optical imaging techniques. We further apply the tools we develop to visualize and

understand some of the most fundamental biological processes that power cellular life. For

example, our lab has developed modulation interferometry, a single-molecule localization-based

super-resolution technique with ~1-2 nm 3D precision and target-locking 3D nanoscopy, a

technique that achieved single-molecule detection in high background, crowded intracellular

environments. These tools have enabled some of the highest resolution single-molecule studies

to date, providing new biological insights that could not be obtained before (e.g. Wang et al. Cell

2016; Li et al., Cell 2019).


Successful applicants will become an important member of our vibrant, interdisciplinary team of

physical and biological scientists. We now develop the next-generation of low-background, noninvasive

and photon-efficient techniques - to further enhance our ability to visualize biological

processes in live cells with single-molecule sensitivity, (sub)-millisecond temporal and (sub)-

nanometer 3D spatial resolution. We also further push the limits of extracting high-resolution

information from weak signals in optically inhomogeneous, thick, multi-cellular environments,

such as tissue explants, 3D organoids and the developing embryo. Finally, we develop new

single-molecule imaging and machine learning technologies for in situ structural

biology, to enable for the first time high-resolution structural studies inside cells.



• Desire to tackle outstanding challenges in optics, microscopy and/or single-molecule


• Ph.D. degree in Physics, Chemistry, Optics, Optical Engineering, Biophysics or a

relevant scientific or engineering field.

• Ability to work effectively in a collaborative, multidisciplinary environment.


Experience with single-molecule detection instrumentation and high/super-resolution optical

imaging (e.g. STED/RESOLFT, 4Pi, MINFLUX, SIM, LLS/SPIM approaches, Adaptive Optics,

etc.), as well as cryogenic and UHV technologies is preferred but not required. Individuals with

additional working knowledge in areas of biochemistry, molecular, cell and developmental

biology and/or genetics are strongly encouraged to apply.


Please send a CV, names and contact

information of three references, and a short description of scientific interests to Dr. Alexandros

Pertsinidis (


MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. 


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